چکیده (انگلیسی):

Magnesium gluconate is an organometallic pharmaceutical compound used for the prevention and treatment of hypomagnesemia. The objective of the current research work was to examine the influence of The Trivedi Effect®-Energy of Consciousness Healing Treatment (Biofield Energy Treatment) on magnesium gluconate for the alteration in the physicochemical, structural, thermal and behavioral properties using PXRD, PSD, FT-IR, UV-vis spectroscopy, TGA, and DSC analysis. Magnesium gluconate was divided into two parts – one part was control without any Biofield Energy Treatment, while another part was treated with The Trivedi Effect®-Energy of Consciousness Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect® treated sample. The PXRD analysis exhibited that the crystallite size of the treated sample was remarkably altered from -63.63% to 80.14% compared with the control sample. The average crystallite size was significantly reduced by 22.14% in the treated sample compared with the control sample. The particle size values in the treated sample at d10 and d50 values were significantly decreased by 4.41% and 8.67% respectively, whereas at d90 value was increased by 3.99% compared to the control sample. The surface area analysis revealed that surface area of the treated sample was significantly increased by 5.21% compared with the control sample. The FT-IR and UV-vis analysis showed that structure of the magnesium gluconate remained identical in both the treated and control samples. The TGA analysis shown four steps thermal degradation of both the samples and the total weight loss of the treated sample was significantly decreased by 4.29% compared with the control sample. The melting temperature of the control and treated samples were 171.02°C and 170.93°C, respectively. The latent heat of fusion was significantly increased by 32.33% in the treated sample compared with the control sample. The TGA and DSC analysis indicated that the thermal stability of the treated sample was significantly improved compared with the control sample. The current study revealed that The Trivedi Effect®-Energy of Consciousness Healing Treatment might produce a new polymorphic form of magnesium gluconate, which could be more soluble and bioavailable along with improved thermal stability compared with the untreated compound. The treated sample could be more stable during manufacturing, delivery or storage conditions than the untreated sample. Hence, The Trivedi Effect® Treated magnesium gluconate would be very useful to design better nutraceutical/pharmaceutical formulations that might offer better therapeutic responses against inflammatory diseases, immunological disorders, stress, aging, and other chronic infections.