چکیده (انگلیسی):

Objectives: To assesses the effects of long term exposure to low dose of acrylamide
(0.4 mg/g) in post-weaning Sprague–Dawley rats on the structure of the reproductive
organ as well as DNA integrity.
Methods: The histological changes in the male and female reproductive organs the
morphological changes in sperms as well as the genotoxic effect of acrylamide were
assessed. The effect acrylamide on pregnancy outcome was evaluated.
Results: Testes of acrylamide-fed rats showed decreased number of seminiferous tubules
containing mature sperms and degenerative changes in sperm germ cell layers. Some
sperms of epididymal cauda showed head deformity. In female, acrylamide included
cystic ovarian changes, degenerative changes of zona pelluida, granulosa cells and oocytes.
Post implantation loss and decrease in the number of full term fetuses were
detected. Resorption sites showed necrotic fetal tissue with vacuolation of amniotic cells.
Conclusion: Acrylamide cause harmful effect on the reproductive organ structure,
fertility and cause extensive DNA damage in peripheral blood lymphocytes.