اثرات ویژگی های فیزیکی پودراستات نشاسته در قرص سازی
Effects of Physical Properties for Starch Acetate Powders on Tableting
نویسندگان |
این بخش تنها برای اعضا قابل مشاهده است ورودعضویت |
اطلاعات مجله |
AAPS PharmSciTech |
سال انتشار |
2002 |
فرمت فایل |
PDF |
کد مقاله |
18981 |
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چکیده (انگلیسی):
The aim of the study was to investigate particle and powder properties of various starch acetate powders, to study the effect of these properties on direct compres-sion characteristics, and to evaluate the modification op-portunity of physical properties for starch acetate pow-ders by using various drying methods. At the end of the production phase of starch acetate, the slurry of starch acetate was dried using various techniques. Particle, powder, and tableting properties of end products were investigated. Particle size, circularity, surface texture, water content and specific surface area varied according to the particular drying method of choice. However, all powders were freely flowing. Bulk and tapped densities of powders varied in the range of 0.29 to 0.44 g/cm3 and 0.39 to 0.56 g/cm3, respectively. Compaction character-istics revealed that all powders were easily deformed under compression, having yield pressure values of less than 66 MPa according to Heckel analysis. All powders possessed a significant interparticulate bond-forming capacity during compaction. The tensile strength values of tablets varied between 10 and 18 MPa. In conclusion, physical properties of starch acetate could be affected by various drying techniques. A large specific surface area and water content above 4% were favorable prop-erties by direct compression, especially for small, irregu-lar, and rough particles.
کلمات کلیدی مقاله (فارسی):
استات نشاسته، تکنیک های خشک کردن، پودر، قرص، اکسیپیانت.
کلمات کلیدی مقاله (انگلیسی):
starch acetate, drying techniques, pow-der, tablet, excipient.
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