چکیده (انگلیسی):

Background: In this study, we have tried to demonstrate the effects of coating
style used in oxygenators on various hematologic and clinical parameters.
Materials and methods: Twenty-seven patients were included in the study, who had undergone
operations because of elective coronary artery disease. Albumin-coated oxygenator
was used in Group I. In Group II, a synthetic polypeptide-coated oxygenator was used.
C1-inhib (complement), C3c, C4, interleukins (IL-1b, IL2, IL-6, IL-10), and tumor necrosis
factor alpha (TNF-a) levels were examined at four different time intervals. Hemoglobin, hematocrit,
leukocyte and platelet counts, drainage, and transfused blood volumes were
analyzed.
Results: Albumin levels were significantly lower in Group I than those in Group II 5 minutes
after the removal of the cross-clamp. Twenty-four hours after the surgery, Group I patients
also had a significantly higher white blood cell count compared to Group II patients. TNF-a
levels in Group I were always expressed in considerably higher amounts than those in Group
II. IL-6 levels were significantly higher in Group I, but IL-10 levels were observed to be higher
in Group II (p < 0.05).
Conclusion: Synthetic polypeptide-coated advanced technology, which employed oxygenators,
had an important attenuator effect on acute phase reactants and also on the inflammatory
response.