چکیده (انگلیسی):

Background: Skin prick tests are widely used to determine sensitivity in allergic diseases. There is limited information
about the natural history of skin sensitization tests and factors that affect them. It was aimed to determine
the changes in skin test results and the factors affecting the reactivity of skin tests after a period of approximately
four years in children with allergic disease.
Methods: SPT of 170 patients among 2485 children with asthma andor allergic rhinitis andor atopic dermatitis,
who underwent SPT between 2005 and 2007, were repeated after an interval of at least 3 years.
Results: The mean age was 10.7 ± 3.1 (5-18) years and 70% of the patients were male. In total 66 (39.0% of
the study population) had a different skin tests result in follow-up. Alterations: loss of sensitivity in 18 (11%) patients,
the formation of a new sensitivity in 37 (22%) patients, and 11 (6%) both gained and lost sensitization.
The presence of atopy in the family, the presence of allergic rhinitis and IgE elevation significantly predicted the
incidence of new sensitization. The presence of sensitization to multiple allergens significantly predicted the incidence
of loss of sensitization.
Conclusions: It is found that there was an alteration of sensitization in 410 children at the end of the average
4-year period. The presence of family atopy, the presence of allergic rhinitis and serum total IgE elevation were
risk factors for the development of new sensitization. On the other hand sensitization to multiple allergens was
risk factors for the loss of sensitization.