چکیده (انگلیسی):

Objective: To understand whether reduced pregnancy and live birth rates for Asian
patients undergoing in vitro fertilization (IVF) could be explained by discrepant rates of
aneuploid embryos.
Methods: A retrospective cohort study of all autologous and donor IVF cycles utilizing
pre-implantation genetic screening (PGS) at a single infertility clinic from January 2012
to December 2013.
Results: After controlling for maternal age, there was no difference in aneuploidy rates
of Caucasian patients compared to Asian patients'. A trend was discerned that embryos of
Caucasians form blastocysts more frequently than those of Asian patients, reaching
significance for patients aged 25 to 30 and 40 to 45, but there was no difference in the
likelihood of having at least one euploid blastocyst to transfer in any age group.
Conclusion: While there may be a slight difference in blastocyst formation rates, there is
no difference in aneuploidy or euploid blastocyst transfer rates between Asian and
Caucasian patients that would explain the discrepancy in IVF outcomes observed between
these patient populations. Possible ethnicity specific differences in non-ploidy
related embryo viability and endometrial receptivity should be investigated as potential
etiologies for this observation.