چکیده (انگلیسی):

Poor aqueous solubility of chemical entities presents a major challenge to modern drug
delivery, because of their low bioavailability. Our aim was to prepare and evaluate a suitable solid
self-emulsifying drug delivery system (SSEDDS) as a potential carrier for rutin. After screening of
various vehicles (surfactants, co-surfactants and oils) and selection of those having the better drug
solubilizing power, liquid SEDDS were formulated. Prepared formulations were evaluated for selfemulsifying
ability and phase diagrams were constructed to optimize the systems. System (S6), prepared
from Triton/Acconon/Labrafac, attained highest drug solubilization capacity, hence, was
selected for the preparation of SSEDDS by adsorption on different nano-structured carriers (Neusilin
, Fujicalin and F-melt) in different ratios. S6 had a very small particle size of
4.849 ±0.001 nm and a high percentage transmittance of 99.31± 0.16%. SSEDDS showing good
flow properties as well as reasonable drug loading capacity were selected for in vitro drug release
studies. The SSEDDS (SS4) composed of Neusilin US2: S6 (1:2) attained the best drug release
properties and was subjected to further characterization (SEM, FTIR and XRD). Conclusion:
The optimized liquisolid dosage form of rutin provided good flowability as well as fast drug release
properties and, therefore, can be suitable for oral delivery system.