چکیده (انگلیسی):

Metoclopramide hydrochloride (MCP) is commonly used for the management of gastrointestinal
disorders. Frequent administration and the undesired side effects (extra pyramidal symptoms)
of the drug on the central nervous system due to the fluctuations of its plasma concentrations
may lead to patient incompliance, and hence, improper therapy. Therefore, the present work will be
devoted to formulate the drug in sustained release formulations. MCP was incorporated in 12 formulae
containing different polymers and/or different polymer ratios. These polymers were hydroxypropylmethyl
cellulose (HPMC), carboxymethylcellulose (CMC) and ethyl cellulose (EC). Sodium
starch glycolate (SSG) was added to some formulae in different amounts in order to soften and/or
disintegrate the tablets. Both direct compression and granulation techniques were used to prepare
the tablets. The physical properties were found to be satisfactory for all the formulae. The dissolution
profiles of the tablets were constructed using the change-over method. The drug release
involved a combination of both diffusion and polymer-chain relaxation mechanisms. The time
required to release 50% of MCP ranged from 1.2 to more than 8 h. Direct compression and dry
granulation techniques produced sufficient sustaining of the drug release. However, the pellets made
by wet granulation released MCP in about 2 h, i.e., pelletization spheronization technique was not
effective in sustaining the drug.