چکیده (انگلیسی):

Purpose: This study aimed to evaluate the macroscopic and microscopic peritoneal findings
after intraperitoneal injection of alcohol in rats.
Methods: From January to February 2012, 20 male rats were used in this study: 15 rats
received intraperitoneal injection of 0.1 mL 99.9% alcohol (group 1: experiment group) and
5 rats received intraperitoneal injection of 0.1 mL normal saline (group 2: control group).
Animals from each group were sacrificed the day after alcohol injection and each week
thereafter. Macroscopic and microscopic examinations of the peritonea and abdominal
cavity were performed in each rat.
Results: There was no significant peritoneal abnormality on macroscopic view, except for a
whitish-colored parietal peritoneum around the injection site in 3 animals from group 1.
In all but 1 of the animals in group 1, mild to moderate peritoneal inflammation or fibrosis
was observed 1 and 2 weeks after alcohol injection. However, the peritoneal abnormality
of alcohol injection had dissipated by week 3. Peritoneal abnormalities were not observed
in group 2.
Conclusion: An intraperitoneal injection of alcohol in rats caused peritoneal inflammation or
fibrosis during the first 2 weeks. However, these peritoneal abnormalities were short-lived
and had completely disappeared after 3 weeks.