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تاریخ امروز
یکشنبه, ۲۸ دی

تحقیقات گروهی کم خونی، درمان و استفاده از انتقال خون آلوژنیک در جراحی سرطان کولورکتال

A cohort investigation of anaemia, treatment and the use of allogeneic blood transfusion in colorectal cancer surgery

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ورودعضویت
اطلاعات مجله Annals of Medicine and Surgery www.annalsjournal.com
سال انتشار 2015
فرمت فایل PDF
کد مقاله 12680

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چکیده (انگلیسی):

Introduction: Preoperative identification and treatment of anaemia is advocated as part of Patient Blood
Management due to the association of adverse outcome with the perioperative use of blood transfusion.
This study aimed to establish the rate of anaemia identification, treatment and implications of this
preoperative anaemia on ARBT use.
Methods: All patients who underwent elective surgery for colorectal cancer over 18 months at a single
Tertiary Centre were reviewed. Electronic databases and patient casenotes were reviewed to yield
required data.
Results: Complete data was available on 201 patients. 67% (n ¼ 135) had haemoglobin tested at presentation.
There was an inverse correlation between tumour size and initial haemoglobin (P < 0.01,
Rs ¼ 0.3). Initial haemoglobin levels were significantly lower in patients with right colonic tumours
(P < 0.01). Patients who were anaemic preoperatively received a mean 0.91 units (95%CI 0e0.7) per
patient which was significantly higher than non-anaemic patients (0.3 units [95%CI 0e1.3], P < 0.01). For
every 1 g/dl preoperative haemoglobin increase, the likelihood of transfusion was reduced by approximately
40% (OR 0.57 [95%CI 0.458e0.708], P < 0.01). Laparoscopic surgery was associated with fewer
anaemic patients transfused (P < 0.01).
Conclusion: Haemoglobin levels should be routinely checked at diagnosis of colorectal cancer, particularly
those with large or right sided lesions. Early identification of anaemia allows initiation of treatment
which may reduce transfusion risk even with modest haemoglobin rises. The correct treatment of this
anaemia needs to be established.

کلمات کلیدی مقاله (فارسی):

کم خونی، انتقال خون، سرطان، جراحی، پیش از عمل

کلمات کلیدی مقاله (انگلیسی):

Anaemia, Blood transfusion, Cancer, Surgery, Preoperative

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