چکیده (انگلیسی):

Objective: The purpose of this study was to investigate the expression of glial cell
derived neurotrophic factor (GDNF), glypican-1 (GPC-1), and matrix metalloproteinase-9
(MMP-9), and their association with clinicopathologic characteristics as well as prognostic
significance in pancreatic cancer.
Methods: Immunohistochemical assessment of GDNF, GPC-1, and MMP-9 was performed in 62
cases of surgically resected pancreatic cancer. Perineural invasion in pancreatic cancer was
observed by marking nerve fiber with S-100, while 16 normal pancreatic tissues were used
as normal control. Correlations of GDNF, GPC-1 and MMP-9 expressions with clinicopathologic
parameters were analyzed. A survival analysis was performed to find the prognostic signifi-
cance.
Results: The expressions of GDNF, GPC-1 and MMP-9 in pancreatic cancer tissue were signifi-
cantly higher than of those in normal pancreatic tissues (41/62 vs. 5/16 for GDNF, 35/62 vs.
2/16 for GPC-1, and 37/62 vs. 3/16 for MMP-9; p < 0.01, respectively). The overexpression
of GDNF, GPC-1, and MMP-9 in pancreatic cancer tissue was significantly related to the perineural
invasion (p < 0.05). Although the overexpression of these genes was related to poor
survival, GPC-1 had an independent prognostic effect on overall survival.
Conclusion: GPC-1 is significantly related to the perineural invasion of pancreatic cancer,
holding some prognostic significance in patients with pancreatic cancer