چکیده (انگلیسی):

The safety of krill oil was assessed in a subchronic toxicity study and in a genotoxicity
test. In a 13-week study, rats were fed krill oil or control diets. There were no differences
noted in body weight, food consumption or in the functional observation battery parameters
in either gender. Differences in both haematology and clinical chemistry values were
noted in the krill oil-treated groups. However these findings were of no toxicological significance.
Significant decreases in absolute and covariant heart weight in some krill oil-treated
animals were noted although no corresponding histological changes were observed. In addition,
periportal microvesicular hepatocyte vacuolation was noted histologically in males
fed 5% krill oil. This finding was not associated with other indications of hepatic dysfunction.
Given that the effects of the 13-week toxicity study were non-toxic in nature, the no
observed adverse effect level (NOAEL) for the conditions of this study was considered to
be 5% krill oil. The genotoxicity experiments documented no mutagenicity of krill oil in
bacteria.