چکیده (انگلیسی):

Optical nanoparticles (NPs) have the potential to provide new tools for diagnosis and treatment
of human diseases, however, their nanotoxicity and biological characteristics are
still unclear. Here, we prepared a series of typical NPs (including gold nanospheres, gold
nanorods, silver nanopheres, silver triangular nanoplates and quantum dots) with different
material and surface chemical modification for nanotoxicity test. Cell proliferation was
investigated by SRB assay where the NPs were co-cultured with cancer cells. It was found
that NPs’ toxicity was highly correlated to different factors—material selection, physical
size/surface area, shape, and surface chemical property, etc. This work has the potential to
provide a uniform and systematic information when they are applied as probes in biological
and medical fields.