چکیده (انگلیسی):

This study is part of an ongoing project to enable the full specification of the Design Space
for roller compactor systems and shows how the processing parameters influence the
behaviour of the product granulate from a placebo formulation. Granulate was produced
using a proprietary roller compactor by varying the compaction pressure and gap width,
and the dynamic, bulk and shear properties of the resultant granulates were measured.
The results demonstrate several rheological properties of the granulate, which have been
shown to be closely correlated with variance in die filling and tablet strength, and are predictably
influenced by the processing parameters.