چکیده (انگلیسی):

A number of studies have suggested that a large subset of children (approximately 70%) who react to
unheated milk or egg can tolerate extensively heated forms of these foods. A diet that includes baked
milk or egg is well tolerated and appears to accelerate the development of regular milk or egg tolerance
when compared with strict avoidance. However, the indications for an oral food challenge (OFC) using
baked products are limited for patients with high specific IgE values or large skin prick test diameters.
Oral immunotherapies (OITs) are becoming increasingly popular for the management of food allergies.
However, the reported efficacy of OIT is not satisfactory, given the high frequency of symptoms and
requirement for long-term therapy.
With food allergies, removing the need to eliminate a food that could be consumed in low doses could
significantly improve quality of life. This review discusses the importance of an OFC and OIT that use low
doses of causative foods as the target volumes. Utilizing an OFC or OIT with a low dose as the target
volume could be a novel approach for accelerating the tolerance to causative foods.