چکیده (انگلیسی):

Combinational therapy of lamivudine and oxymatrine has been employed in the battle against
hepatitis B virus in clinical setting. However, the pharmacokinetic behavior of the drug or
active metabolism in intravenous/oral co-administration regime is poorly investigated. Herein,
we evaluated the pharmacokinetic characteristic through a tailor-designed 3 way crossover-
Latin square experiment in adult male beagle dogs. Six dogs were randomly treated by
intravenous administration of lamivudine (2.5 mg/kg), oxymatrine (15 mg/kg) and combinational
dosage, named as intravenous regime. Meanwhile the other six dogs were orally
administrated with lamivudine (2.5 mg/kg), oxymatrine (15 mg/kg) and combinational dosage,
named as oral regime. The pharmacokinetic feature in simultaneous oral treatment appeared
to have no significant difference when compared with individual administration,
even including matrine, the active metabolite of oxymatrine. In intravenous regime, the main
pharmacokinetic parameters of simultaneous administration were nearly consistent with
intravenous regime remedy.The collaborated application of lamivudine and oxymatrine contributed
to non-distinctive pharmacokinetic fluctuations of beagle dogs in intravenous/
oral regime, compared with individual employment, which established a vital base for the
clinical co-administration against hepatitis B. Furthermore, the present study demonstrated
that the determination of pharmacokinetics between combinational and individual
therapy might assist in the development of drug compatibility in clinical therapy.