چکیده (انگلیسی):

Background/Objective: Pancreatic fistula (PF) is the most common and challenging
complication after pancreaticoduodenectomy (PD). This meta-analysis aimed to evaluate
the impact of pancreaticogastrostomy (PG) versus pancreaticojejunostomy (PJ) on
occurrences of postoperative PF.
Methods: A systematic literature search in the Medline, EMBASE, OVID, and Cochrane databases
was performed to identify all eligible randomized controlled trials (RCTs). Pooled estimates
were presented with 95% confidence intervals (CI).
Results: Six RCTs involving 1005 patients met the inclusion criteria. The incidence of PF [odds
ratio (OR) 0.58, 95% CI, 0.42e0.81; p Z 0.001], intra-abdominal abscess or collections (OR
0.43, 95% CI, 0.28e0.65; p < 0.001), and biliary fistula (OR 0.28, 95% CI, 0.11e0.74;
p Z 0.01) were found to be significantly lower in the PG group than in the PJ group. There
was no significant difference in overall morbidity, other complications, hospital mortality, or
length of hospital stay between the two groups.
Conclusion: The meta-analysis showed that PG following PD represents a safe procedure associated
with fewer PFs compared with PJ.