چکیده (انگلیسی):

Background: The aim of this study was to compare 6 weeks short-term moderate intensity aerobic exercise and dieting on serum metabolomics and cardio-metabolic risk factors in pre-menopausal women. Methods: Ninety previously inactive overweight and obese (BMI 25e35 kg/m2 ) women (age 41.5 7.6 years) were randomized to either a 6-week Nordic walking exercise program (EX, n ¼ 45) or dietary counseling group (DI, n ¼ 45). Body composition, serum glucose, insulin and lipids were measured. Serum low-molecular-weight metabolites and lipid constituents were analyzed by nuclear magnetic resonance spectroscopy. Measurements were done at baseline and 7 days after the last training session. Results: Six weeks aerobic exercise program yielded reductions in serum free fatty acids (34.7%, 95% confidence interval (CI), 50 to 18, p < 0.001), glucose (9.6%, 95%CI, 15 to 4, p < 0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) (28.7%, 95%CI, 48 to 10, p ¼ 0.005) without changes in body weight or fat mass. Diet counseling resulted in loss of body weight (1.5%, 95%CI, 2.3 to 0.7, p ¼ 0.001) but no changes in free fatty acids, fasting glucose, or HOMA-IR were found. Conclusion: Our results indicate that small weight loss does not produce measurable health benefits, whereas short-term regular aerobic exercise can improve glucose and lipid metabolism even in the absence of weight loss in previously sedentary overweight and obese women. Copyright