چکیده (انگلیسی):

Objective: There are controversies about the benefits of prophylactic antibiotics
in the prevention of postoperative surgical site infection (SSI) in mesh herniorrhaphy for a long
time. This study aimed to evaluate the effectiveness and efficacy of systemic prophylactic cefazolin
in prevention of wound infection in various types of hernia repair with mesh materials.
Methods: This is a prospective randomized control study. We evaluated wound infection rates
in 395 patients with various kinds of hernia who underwent elective mesh repair using polypropylene
mesh from 2007 to 2011. A total of 237 (60.0%) patients received prophylactic cefazolin
(study group) and the remaining 158 (40.0%) patients did not receive any prophylactic antibiotics
(control group). Patients were followed for infection at the following periods after the
operation by an independent surgeon: 10 days, 30 days, 12 months, and then annually for at
least 2 years.
Results: Eight (2.03%) patients had infection in the site of surgery [2 (1.27%) in the control
group and 6 (2.53%) in the study group]. The distribution of infection was not significantly
different between the two groups (p Z 0.364). The superficial infections were managed by
drainage and irrigation. One patient from the study group developed deep SSI and was readmitted
and subsequently received antibiotic therapy, drainage, and debridement.
Conclusion: Preoperative administration of single-dose cefazolin for prosthetic hernia repairs
did not markedly decrease the risk of wound infection. Our results do not support the use of cefazolin as a prophylactic antibiotic for various kinds of abdominal wall hernia repair with
mesh.