چکیده (انگلیسی):

Objective: To study the influence of cisplatin implants on transplantation tumor growth
and the expression of tissue kallikrein-7 (KLK7) and E-cadherin (E-cad) in tumor-bearing
mice with gastric cancer.
Methods: BALB/c nude mice were collected as experimental animal and were randomly
divided into model control group (Group A), tail intravenous injection of cisplatin group
(Group B), intratumor injection of cisplatin group (Group C) and cisplatin implants
treatment group (Group D). After the drugs intervening, the weight and volume of
transplantation tumors were measured on Day 20, Day 30 and Day 40 and serum and
KLK7 and E-cad contents in transplanted tumor tissue were examined.
Results: On Day 20, Day 30 and Day 40 after treatment, the weight and volume of
transplantation tumors of tumor-bearing mice in four groups were different (Group
A > Group B > Group C > Group D). The contents of KLK-7 and E-cad in tumor tissue
and serum of tumor-bearing mice in four groups were different (Group A > Group
B > Group C > Group D in KLK-7) and (Group A < Group B < Group C < Group D in
E-cad). The weight and volume, and KLK7 and E-cad contents of transplantation tumors
in four groups were significant difference (P < 0.05).
Conclusion: Cisplatin implants can inhibit the growth of transplanted tumor tissue and
down-regulated KLK7 expression and up-regulated E-cad expression of tumor-bearing
mice with gastric cancer.