چکیده (انگلیسی):

The aim was to develop and optimize fast dissolving oro-dispersible films of granisetron
hydrochloride (GH) by two-factor, three-level Box–Behnken design as the two independent variables
such as X1 (polymer) and X2 (plasticizer) were selected on the basis of the preliminary studies
carried out before the experimental design is being implemented. A second-order polynomial equation
to construct contour plots for the prediction of responses of the dependent variables such as
drug release (Y1), Disintegration time (Y2), and Y3 (Tensile strength) was studied. The Response
surface plots were drawn, statistical validity of the polynomials was established to find the compositions
of optimized formulation which was evaluated using the Franz-type diffusion cell. The
designs establish the role of the derived polynomial equation and contour plots in predicting the
values of dependent variables for the preparation and optimization.