چکیده (انگلیسی):

Several reports have shown antimicrobial and anticancer activities of mucous glycoproteins extracted from the
giant African snail Achatina fulica. Anticancer properties of the snail mucous peptides remain incompletely revealed.
The aimof this study was to predict anticancer peptides fromA. fulica mucus. Two of HPLC-separatedmucous
fractions (F2 and F5) showed in vitro cytotoxicity against the breast cancer cell line (MCF-7) and normal
epithelium cell line (Vero). According to the mass spectrometric analysis, 404 and 424 peptides from the F2
and F5 fractions were identified. Our comprehensive bioinformatics workflow predicted 16 putative cationic
and amphipathic anticancer peptides with diverse structures from these two peptidome data. These peptides
would be promising molecules for new anti-breast cancer drug development.
© 2015 E-kobon et al. Published by Elsevier B.V. on behalf of the Research Network of Computational and
Structural Biotechnology. This is an open access article under the CC BY license
(http://creativecommons.org/licenses/by/4.0/).