چکیده (انگلیسی):

Objective: To explore the effects of arteannuin B, arteannuic acid and scopoletin on the
pharmacokinetics of artemisinin in mice.
Methods: Artemisinin and a combination of artemisinin, arteannuin B, arteannuic acid
and scopoletin were administered together to mice via oral administration. Blood samples
were collected at different time intervals and pretreated by liquid–liquid extraction. The
contents of four compounds in mouse plasma were determined by a validated HPLC-MS/
MS method.
Results: Compared to single artemisinin group, the Cmax values from the combination
group rose from 947 ng/mL to 1254 ng/mL. AUC(0-t) (2371 h ng/mL) was significantly
higher than that from single artemisinin group (747 h ng/mL). The peak time lag and the
CL values reduced at a proportion of 66%.
Conclutions: Arteannuin B, arteannuic acid and scopoletin can markedly affect the
pharmacokinetics of artemisinin.