چکیده (انگلیسی):

Objective: To estimate to what extent the mixture of ursolic acid and oleanolic acid, in
addition to the antitubercular standard regime, affects the hepatotoxicity profile.
Methods: Liver injury was induced in male BALB/c mice by administering, per os and
daily for 11 weeks, a combination of anti-Tubercular (anti-TB) agents Rifampicin (10 mg/
kg), Isoniazid (10 mg/kg), and Pyrazinamide (30 mg/kg). The ursolic acid and oleanolic
acid mixture at doses of 100 or 200 mg/mouse/day was subcutaneously injected
throughout the entire study period (11 weeks). Biochemical and hematological analysis
was supplemented by liver histological examination.
Results: Animals treated with the mixture of triterpenic acids exhibited significantly
decreased aspartate transaminase and alanine aminotransferase levels and amelioration of
the histopathological alterations produced by the anti-TB drugs.
Conclusions: The triterpene mixture was able to prevent the steatosis induced by the
anti-TB drugs.