چکیده (انگلیسی):

The purpose of this study was to develop a drug-loaded nanosystem that has the ability to
achieve flexible yet rate-controlled release of model drug isoniazid (INH) employing either an aqueous
or emulsion-based salting-out approach. Formulation conditions were aimed at reducing the polymeric
size with subsequent rate-modulated INH release patterns from the polymeric nanosystem. The
emulsion-based salted-out nanosystems had particle sizes ranging from 77–414 nm and a zeta potential
of −24 mV. The dispersant dielectric constant was set at 78.5 and a conductivity of 3.99 mS/cm achieved.
The reduced nanosystem size of the aqueous-based approach has demonstrated an intrinsically enhanced
exposure of methacrylic acid-ethyl acrylate to zinc sulphate which was employed as a crosslinking
reagent. This resulted in robustly interconnected polymeric supports in which INH was efficiently
embedded and subsequently released. The multi-layer perceptron data obtained showed that the
aqueous and emulsion-based salting out approaches had Power (law) (MSE=0.020) and Linear (MSE=
0.038) relationships, respectively. Drug release from the nanosystems occurred in two phases with an
initial burst-release in aqueous-based nanosystems (30–100%) and significantly lower bursts observed in
emulsion-based nanosystems (20–65%) within the first 2 h. This was followed by a gradual exponential
release phase over the remaining 12 h. The nanosystems developed demonstrated the ability to control
the release of INH depending on the formulation approach adopted.