چکیده (انگلیسی):

The purpose of this study was to enhance the dissolution of
oleanolic acid by solid dispersions consisting of the drug, a
polymeric carrier, and a surfactant. Binary solid dispersions
consisting of oleanolic acid and polyvinylpyrrolidone were
prepared for comparison. Polysorbate 80, a nonionic surfactant,
was incorporated into binary solid dispersions as the
third component to prepare ternary solid dispersions. Solid
dispersions were characterized by differential scanning calorimetry,
Fourier transform infrared spectroscopy, and dissolution
tests. The crystallinization of OAwas prohibited in
solid dispersions. Both the binary and ternary solid dispersions
enhanced the dissolution of OA. Moreover, the dissolution
of ternary solid dispersion was faster compared with
that of binary solid dispersion. Polysorbate 80 played an
important positive role in dissolution of the solid dispersion.