چکیده (انگلیسی):

The purpose of this research was to study whether the bioavailability
of lovastatin could be improved by administering
lovastatin solid lipid nanoparticles (SLN) duodenally to
rats. Lovastatin SLN were developed using triglycerides by
hot homogenization followed by ultrasonication. Particle
size and zeta potential were measured by photon correlation
spectroscopy. The solid state of the drug in the SLN and lipid
modification were characterized. Bioavailability studies were
conducted in male Wistar rats after intraduodenal administration
of lovastatin suspension and SLN. Stable lovastatin
SLN having a mean size range of 60 to 119 nm and a zeta
potential range of –16 to –21 mV were developed. More than
99% of the lovastatin was entrapped in the SLN. Lovastatin
was dispersed in an amorphous state, and triglycerides were
in β1 form in the SLN. In vitro stability studies showed the
slow release and stability of lovastatin SLN. The relative
bioavailabilities of lovastatin and lovastatin hydroxy acid
of SLN were increased by ~173% and 324%, respectively,
compared with the reference lovastatin suspension.