چکیده (انگلیسی):

The purpose of writing this review on floating drug delivery
systems (FDDS) was to compile the recent literature
with special focus on the principal mechanism of floatation
to achieve gastric retention. The recent developments of
FDDS including the physiological and formulation variables
affecting gastric retention, approaches to design single-unit
and multiple-unit floating systems, and their classification
and formulation aspects are covered in detail. This review
also summarizes the in vitro techniques, in vivo studies to
evaluate the performance and application of floating systems,
and applications of these systems. These systems are
useful to several problems encountered during the development
of a pharmaceutical dosage form.