چکیده (انگلیسی):

Background:Prediabetes is a high-risk state for diabetes development, but little is known about the factors associated
with this state. The aim of the study was to identify modifiable risk factors associated with the presence of prediabetes
in men and women.
Methods:Cohort Study in Primary Health Care on the Evolution of Patients with Prediabetes (PREDAPS-Study) is a
prospective study on a cohort of 1184 subjects with prediabetes and another cohort of 838 subjects without glucose
metabolism disorders. It is being conducted by 125 general practitioners in Spain. Data for this analysis were collected
during the baseline stage in 2012. The modifiable risk factors included were: smoking habit, alcohol consumption, low
physical activity, inadequate diet, hypertension, dyslipidemia, and obesity. To assess independent association between
each factor and prediabetes, odds ratios (ORs) were estimated using logistic regression models.
Results:Abdominal obesity, low plasma levels of high-density lipoprotein cholesterol (HDL-cholesterol), and
hypertension were independently associated with the presence of prediabetes in both men and women. After
adjusting for all factors, the respective ORs (95% Confidence Intervals) were 1.98 (1.41-2.79), 1.88 (1.23-2.88)
and 1.86 (1.39-2.51) for men, and 1.89 (1.36-2.62), 1.58 (1.12-2.23) and 1.44 (1.07-1.92) for women. Also, general
obesity was a risk factor in both sexes but did not reachstatistical significance among men, after adjusting
for all factors. Risky alcohol consumption was a risk factor for prediabetes in men, OR 1.49 (1.00-2.24).
Conclusions:Obesity, low HDL-cholesterol levels, and hypertension were modifiable risk factors independently
related to the presence of prediabetes in both sexes. The magnitudes of the associations were stronger for men than
women. Abdominal obesity in both men and women displayed the strongest association with prediabetes. The
findings suggest that there are some differences between men and women, which should be taken into account
when implementing specific recommendations to prevent or delay the onset of diabetes in adult population.