چکیده (انگلیسی):

Atherosclerosis, as the leading cause of mortality, is usually regarded as a systemic disease and several well-identified risk factors have been implicated in its pathogenesis. Low or highly oscillatory wall shear stress has mainly been linked to the development of atherosclerosis. Conditions under which human blood can be considered Newtonian for the purpose of arterial flow modeling are investigated with emphasis on near wall shear stresses. The Lattice Boltzmann method is implemented in parallel for both Newtonian and non-Newtonian models of blood and then examined in the context of steady and oscillatory flows. As the lattice method permits to adjust the morphology of the computational domain during the solving process, the artery walls are reshaped in a recursive manner by the progressive accumulation of deposits according to the conventional OSI criterion. Regions subjected to partial obstructions identified qualitatively well with those susceptible to atherosclerosis in the in vivo sample, thereby approving this criterion by verifying its accumulative effect. The present work demonstrates
the suitability of LB method for studying flows across geometries that transform due to atherosclerotic progression and permits to explain the trend of deposit distribution across time.