چکیده (انگلیسی):

The aim of this work was to find a
drying procedure for moist sucralfate gel capable of
producing dried sucralfate gel that retains the original
gel properties of bioadhesion, rheology, and
micromeritics. Spray-drying and microwave-drying
procedures were employed. Mannitol was used as a
gel-protective substance during the drying processes.
The spray drying of moist sucralfate gel gave rise to a
powder whose water suspensions showed
significantly reduced viscosity. The bioadhesion of
spray-dried sucralfate gel was strongly reduced by
drying. When mannitol was used as a gel protector,
the spray-dried sucralfate in part maintained the
original bioadhesion of moist sucralfate gel. The
preparation of a dried sucralfate gel retaining the
bioadhesion characteristics, avoiding the use of
mannitol, was made possible using the microwavedrying
procedure. The microwave-dried product
possesses a granular morphology suitable for direct
compression because it is a free flowing and strongly
coherent granular powder.