چکیده (انگلیسی):

The purpose of this investigation was
to develop a rapidly disintegrating calcium carbonate
(CC) tablet by direct compression and compare it with
commercially available calcium tablets. CC tablets were
formulated on a Carver press using 3 different forms of
CC direct compressed granules (Cal-Carb 4450®, Cal-
Carb 4457®, and Cal-Carb 4462®). The breaking
strength was measured using a Stokes-Monsanto
hardness tester. The disintegration and dissolution
properties of the tablets were studied using USP
methodology. The calcium concentration was
determined by an atomic absorption spectrophotometer.
Scanning electron microscopy was used to evaluate the
surface topography of the granules and tablets. Breaking
strength of Cal-Carb 4450®, Cal-Carb 4457®, and Cal-
Carb 4462® tablets was in the range of 7.2 to 7.7 kg, as
compared with a hardness of 6.2 kg and 10 kg for the
commercially available calcium tablets Citracal® and
Tums®, respectively. The disintegration time for the
tablets presented in the order earlier was 4.1, 2.1, 1.9,
2.9, and 9.7 minutes, respectively. The dissolution
studies showed that all formulations released 100% of
the elemental calcium in simulated gastric fluid in less
than 20 minutes. In summary, this study clearly
demonstrated that quick disintegrating CC tablets can be
formulated without expensive effervescence technology.