چکیده (انگلیسی):

Background: High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic
states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at
100 mg, 500 mg and 1500 mg doses in healthy subjects.
Methods: This was a randomized, double-blind, single-dose, 4-way crossover study. Pharmacokinetic measures
were calculated.
Results: The AUC0-10 hr and Cmax values increased nonlinearly between100 mg and 1500 mg. The slope of the
AUC0-10 hr vs dose, as well as the Cmax vs dose, plots are steepest at the lowest thiamine doses.
Conclusion: Our study demonstrates that high blood levels of thiamine can be achieved rapidly with oral thiamine
hydrochloride. Thiamine is absorbed by both an active and nonsaturable passive process.