چکیده (انگلیسی):

To control the minimum effective dose, and reduce the number and quantity of administered
potent drugs are unique features of advanced drug delivery in situ forming gel formulation.
The efficacy, consistency, and increasing the application of existing injection therapies can be
enhanced through optimization of controlled released systems by using FDA approved biodegradable
PLGA (poly-D,L-lactide-co-glycolide) polymer. The purpose of this study was to develop different
in situ forming implant (ISFI) formulations of buprenorphine hydrochloride for post
treatment of drug addicts, acute and chronic pains.
The drug releases from different ISFIs membranes with and without Tween 80 were compared
over a period of time. Kinetic equation followed the Korsmeyer–Peppas model, as the plots showed
high linearity. The influence of this additive on polymer properties was investigated using differential
scanning calorimetry (DSC), and the membranes structure was studied by X-ray diffractometry
(XRD) and scanning electron microscope (SEM).
Data revealed that Tween 80 modified the drug release pattern using diffusion mechanism and
decreased the glass transition temperature (Tg) significantly. The degree of crystallinity was
decreased after phase inversion which helps the dissolution of drug from membrane. The porosity
of modified membranes was in accordance with release profiles.