چکیده (انگلیسی):

Study objectives were to develop a unique floating ring capsule dosage form which
combines gastric soluble and insoluble portions, and to evaluate its suitability for stomach specific
drug delivery. New floating ring capsules were developed using different polymers and were compared
for various parameters. The formulation with HPMC and sodium CMC has better floating
properties. The effects of polymers concentration on drug release were studies by in vitro release
studies. The interaction studies of combined drug with polymers were determined using FT-IR
spectroscopy. The entrapped air within the gel barrier and lower densities of HPMC and sodium
CMC resulted in better floating behavior. Steady slow gel formations showed prolonged drug
release. The in vitro release rates were generally found to be faster with low concentration of carbopol
showing release within 2 h, while formulations containing high amount of HPMC showed
release in 8 h. In particular, the higher concentration of HPMC formulation shows the best drug
release performance. A very low change in peak shift was observed only with sodium alginate formulations.
Further, FT-IR measurements confirmed the absence of any chemical interactions.
Results indicate that new floating ring capsule is a promise dosage form for stomach specific
delivery.