ارزیابی بالینی مقایسه ای کتوتیفن و سدیم مونتلوکاست در بیماران مبتلا به آسم عراق
Comparative clinical evaluation of ketotifen and montelukast sodium in asthmatic Iraqi patients
نویسندگان |
این بخش تنها برای اعضا قابل مشاهده است ورودعضویت |
اطلاعات مجله |
Saudi Pharmaceutical Journal |
سال انتشار |
2010 |
فرمت فایل |
PDF |
کد مقاله |
17050 |
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چکیده (انگلیسی):
Asthma is a common and chronic inflammatory condition of the airways whose cause is
not completely understood. Although many classes of drugs are used for management of asthma,
the response is variable due to multifactor reasons. This study was designed to evaluate the outcome
of using ketotifen or montelukast sodium in Iraqi asthmatic patients. Single blinded randomized
clinical trial was utilized, in which 100 asthmatic patients were recruited from Al-Karama hospital
and randomized into two groups; 1st group (50 patients, treated with ketotifen for 4 weeks) and 2nd
group (50 patients treated with montelukast sodium for 4 weeks). Asthma symptom score and
wheezing were recorded at the beginning (first visit) and at the end of the study (after one month).
Pulmonary function tests (PFTs) were performed by spirometry, and the patients’ use of asthma
drugs and their symptoms were evaluated at each visit. The result showed that asthma symptom,
chest wheezing, and PFT values were significantly improved in the two groups at the end of the
study compared to first visit (p<0.05). All symptoms were significantly lower and PFT values were
higher in the 2nd group compared to 1st group (p< 0.05). In conclusion, both ketotifen and montelukast
sodium showed significant changes in asthma symptoms and PFT after one month of treatment,
but the changes were more significant with montelukast group (2nd group) compared with
ketotifen group (1st group) and this indicate that montelukast was more effective than ketotifen
in treatment of asthmatic patients.
کلمات کلیدی مقاله (فارسی):
کتوتیفن؛ سدیم مونتلوکاست؛ نمره علائم آسم؛ تست عملکرد ریوی
کلمات کلیدی مقاله (انگلیسی):
Ketotifen; Montelukast sodium; Asthma symptom score; Pulmonary function test
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