چکیده (انگلیسی):

Objective: To investigate –844C>T single nucleotide polymorphism (SNP) present in
the promoter of cell death pathway gene FASLG with male infertile phenotype. Methods:
Genotyping for SNP FASLG (rs763110) was done by polymerase chain reaction followed by
analysis with specific endonuclease (PCR-RFLP). DNA sequencing was used to ascertain PCRRFLP
results. Results: FASLG –844C>T polymorphism, allele and genotype distribution did not
differ significantly between patients and controls (OR: 1.03, 95% CI= 0.7638 to 1.3952, P=0.83).
Thus SNP-844C>T of the FASLG gene is not associated with male infertility risk in the analyzed
patients. Conclusion: Human male infertility is a complex disorder and thus other genetic or
environmental factors may be contributing to the complex etiology, and further study in other
region of Indian populations will verify whether it is associated with male infertility risk.