چکیده (انگلیسی):

Introduction: The use of prosthetic patches of non-absorbable materials represents a valid tool in the
treatment of abdominal wall and diaphragmatic defects in pediatric age. In recent years research has
developed biological dermal scaffolds made from a sheet of acellular matrix that can provide the desired
support and reduce the occurrence of complications from non-absorbable implant. We present our
experience and a systematic review to evaluate the use of biologic prosthesis for abdominal wall closure
in pediatric patients.
Methods: The study from January 2009 to January 2015 involved 20 patients treated with Permacol™
implant. We observed postoperative complications only in patients treated for abdominal wall closure,
which is the major indication for the use of Permacol™. We conducted a systematic review and metaanalysis
(according to PRISMA) on PubMed/Medline, Scopus and EMBASE regarding the use of biological
prosthesis in pediatric population considering the incidence of complications as the primary
outcome.
Results: 3/20 patients experienced complications: 2 patients with skin necrosis healed conservatively
and 1 of them developed laparocele. Thus only 1 patient with incisional hernia had significant surgery
complication. In patients who were permanently implanted with Permacol™ it has not determined
adverse reactions with optimal functional outcome.
Conclusions: In accordance with the few data (case reports and case series) reported in literature about
pediatric patients, our experience in different pathologies and applications has shown the effectiveness
of Permacol™, in particular for the non-occurrence of infections, that often affect the use of prosthesis.