چکیده (انگلیسی):

Objective: The present study was performed to determine whether expansion of the
CAG repeat in exon 1 of the AR gene is correlated with non-obstructive azoospermia
(NOA) in Iranian infertile men.
Methods: The CAG repeat length was investigated in 307 Iranian men, 104 infertile men
with NOA and 203 fertile controls using primers flanking the CAG repeat region in exon
1 of the AR gene.
Results: The most common allele in the patients and controls was 23 (18.39%) and 21
(19.70%) CAG repeats with the mean number of 21.97 ± 2.772 and 21.10 ± 2.674,
respectively (P = 0.013).
Conclusion: Although our results indicate a significant negative correlation between the
length of CAG repeat and male infertility, however, other genetic modifiers may be
required in order to cause male infertility.