چکیده (انگلیسی):

Objective: To study the histomorphological changes with reference to estradiol valerate
administration in aged female albino rats.
Methods: The observations showed in young, aged and aged administered with estradiol
valerate (Progynova tablets) at the dose of 2 mg/day through oral gavages for one week.
The histomorphological changes were observed in ovary, uterus, vagina and liver.
Results: Estradiol velerate administration improves the ovarian stroma and germinal
epithelium. The vascular hyaline degeneration reduces. Vascular protective effects of
estrogen are well established. The administration may be associated with endometrial
hyperplasia and neoplasia. The stroma was comparatively less edematous with less active
endometrial glands. The uteri exhibited endometrial epithelial cell pseudo stratification
and hypertrophy. The vaginal histoarchitecture showed increased epithelial proliferation
of the vaginal wall and improving thickening. Estradiol velerate does not showed any
effect on liver architecture.
Conclusions: The administration of estradiol valerate showed its vascular protective
effects. It does not showed any effect on liver architecture.