چکیده (انگلیسی):

Objective: To investigate the frequency of Pro12Ala polymorphism in PPAR gamma
gene among PCOS of South Indian Population. Understanding this polymorphism may
help us in better diagnosis prevention and therapeutic approaches towards management of
PCOS.
Method: A total of 75 women with the diagnosis of PCOS and 75 healthy controls were
included in this study. The Pro12Ala variant in the PPAR gamma gene was analysed by
PCR-RFLP.
Results: Genotypic frequencies for PPAR gamma gene Pro12Ala polymorphism showed
the frequency of Pro/Pro genotypes was 77% in PCOS and 81% in controls. The odds
ratio was 0.71 (95% CI 0.31–1.63) and 2.66 (95% CI 0.21–32.9) and alleles expressed
0.87 (95% CI 0.42–1.79). Regarding hormone levels, there were significant differences
between PCOS and non PCOS.
Conclusion: PPARg2 gene Pro12Ala polymorphism was supposed to be susceptible
genes in PCOS. The present study demonstrated that there is a statistical difference between
the distributions of PPAR gamma Pro12Ala polymorphism in South Indian
Population.