چکیده (انگلیسی):

Objective: To investigate the changes in profile of the oxidant and antioxidant indicators
throughout pregnancy in goats.
Methods: Estrus in goats was synchronized using an intravaginal progestogen impregnated
sponge and the buck was introduced in the herd during the experiment for breeding
purpose. Serum nitric oxide (NO) as standard angiogenic marker, total antioxidant capacity
(TAC) as a cryoprotectant indicator, total peroxide (TPX) as a pathogenetic
effector were measured, followed by calculation of OSI% (TPX/TAC) × 100 as a reflector
of the oxidant/antioxidant status, and malondialdehyde were estimated.
Results: Compared with values in singleton and twins bearing goats, TAC values in
multiple bearing goats were higher in 4th month and lower in 5th month (P < 0.05).
Values of TPX were lower in multiple bearing goats in 4th month and higher in 5th
month (P < 0.05) when compared with singleton and twins bearing goats. In contrary,
NO values started to increase from the 2nd month until 4th month of gestation in all
pregnant goats. However, the NO was lower in 5th month (P < 0.05) in multiple bearing
goats. Values of NO were negatively correlated with OSI% in all bearing goats.
Conclusion: Knowing the relationship between the fetal number and oxidative stress
indicators could be useful in the clinical management of such pregnancies and could be
useful in the early detection or prediction adverse pregnancy outcome. Particularly, the
4th and 5th month of gestation increases the liability to reactive oxygen species in goats.