چکیده (انگلیسی):

Mucosal barriers encounter an environment that is rich in pathogens that possess mechanisms for invading
mucosal tissues. These barriers also encounter innocuous antigens, such as foods, airborne antigens, and microbiota.
The mucosa has developed a sophisticated immune system that can mount robust immune responses
against pathogenic antigens, while maintaining mucosal tolerance against non-pathogenic antigens.
Accumulating evidence indicates that the mucosal epithelium, dendritic cells, and a subtype of T cells with
regulatory properties play important roles in the development and maintenance of mucosal tolerance. Moreover,
the micribiota also contribute to regulating the mucosal immune system. A failure to develop or the breakdown
of mucosal tolerance can result in allergic diseases, such as food allergy and asthma. By taking advantage
of the unique characteristics of the mucosal immune system, strategies that induce regulatory cells in vivo
and, thereby, reconstitute mucosal tolerance may be used to develop novel therapies that are suitable for treating
or preventing of allergic diseases.